HEADSpAcE Objectives

The primary objectives of HEADSpAcE are to:

1. assess the socioeconomic and logistical reasons for delays in diagnosis;
2. determine the most accurate way to assess HPV-positive oropharyngeal cancer in the clinical setting;
3. identify the extent of HPV-positive oropharyngeal cancers in Europe and South America, and assess lifestyle and genetic predictors of HPV infection;
4. conduct comprehensive genomic evaluation of 800 head and neck cancers from South America and Europe;
5. perform an analysis of germline variation to identify susceptibility loci for head and neck cancer outcome;
6. determine whether liquid biopsies can be informative for head and neck cancer clinical care; and
7. establish guidelines for implementation in clinical care.